Abstract
A series of hydantoin derivatives has been discovered as highly potent nonpeptide antagonists for the human CCR5 receptor. The synthesis, SAR, and biological profiles of this class of antagonists are described.
MeSH terms
-
Anti-HIV Agents / chemistry
-
Anti-HIV Agents / pharmacology
-
Anti-HIV Agents / therapeutic use*
-
CCR5 Receptor Antagonists*
-
HIV Infections / drug therapy*
-
HIV-1 / isolation & purification
-
Humans
-
Hydantoins / chemistry
-
Hydantoins / pharmacology
-
Hydantoins / therapeutic use*
Substances
-
Anti-HIV Agents
-
CCR5 Receptor Antagonists
-
Hydantoins